Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis - PubMed
3 hours ago
- #OCD
- #neuroimaging
- #cortical microstructure
- Study compares cortical microstructure in OCD patients vs. healthy controls using gray/white matter contrast (GWC).
- OCD patients show higher GWC in occipital and frontal regions, indicating altered intracortical myelination.
- Higher GWC correlates with gray matter macrostructure alterations and specific OCD symptoms like sexual/religious obsessions.
- Findings suggest a link between cortical microstructure, macrostructure, and clinical presentation in OCD.