The influence of polymorphisms in cytokine genes on pain and response to palliative radiotherapy in multiple myeloma patients: prospective observational study - PubMed
3 hours ago
- #cytokine polymorphisms
- #multiple myeloma
- #palliative radiotherapy
- Study examines the impact of cytokine gene polymorphisms on pain severity and response to palliative radiotherapy in multiple myeloma patients.
- 81 patients were analyzed for pain severity and analgesic use before and after radiotherapy, focusing on 12 polymorphisms in 6 cytokine genes (IL-6, IL-10, TNFα, IL-1α, IL-1β, IL-1RA).
- Key findings: Karnofsky index ≥60% and IL1RN rs2234677 GG genotype significantly influenced severe pain pre-radiation.
- IL1A rs1800587 CC and IL1B rs1143634 CC genotypes showed better response to radiotherapy.
- IL1RN rs315952 CC genotype correlated with faster radiation response.
- Highlights the role of inflammatory interleukin gene polymorphisms in pain severity and radiotherapy efficacy.