Efficacy of rTMS and TBS on the motor symptoms in Parkinson's disease: a network meta-analysis - PubMed
7 hours ago
- #Network meta-analysis
- #Parkinson's disease
- #Transcranial magnetic stimulation
- The study evaluates the effects of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) on motor symptoms in Parkinson's disease (PD) using a network meta-analysis.
- Multi-session continuous TBS (cTBS) was found to be significantly more effective than single-session cTBS in improving motor symptoms.
- High-frequency (HF) rTMS targeting the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC), as well as cTBS targeting the supplementary motor area (SMA), showed significant improvements in global motor function.
- HF rTMS + SMA was most effective in improving freezing of gait and time up and go test performance.
- Low-frequency rTMS targeting SMA was best for improving bradykinesia, while HF rTMS + M1 improved quality of life.
- All interventions were well tolerated, with no significant adverse effects reported.
- The study concludes that multi-session TBS protocols are superior to single-session ones, and specific stimulation targets should be chosen based on the motor symptoms being addressed.