GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration - PubMed
4 hours ago
- #GBA1 mutation
- #LCN2
- #neurodegeneration
- GBA1 F213I mutation exacerbates dopaminergic neuron loss in the substantia nigra in a PD mouse model.
- LCN2 is significantly upregulated in multiple GBA1 mutation and inhibition models, as confirmed by various techniques.
- Stereotactic injection of recombinant Lcn2 protein promotes α-synuclein accumulation and dopaminergic neuron loss.
- LCN2 antibodies reduce intracellular ROS levels induced by GBA1 mutants in vitro.
- Deletion of Lcn2 alleviates dopaminergic neuron loss in GBA1 mutation-associated PD models.