Elovl6 inhibits colorectal cancer progression through stearic acid-mediated mitochondrial fusion and metabolic reprogramming - PubMed
7 days ago
- #mitochondrial fusion
- #colorectal cancer
- #lipid metabolism
- Elovl6 is identified as a critical regulator in colorectal cancer (CRC) progression.
- Clinical data show significant down-regulation of Elovl6 in colon cancer tissues, correlating with poor patient prognosis.
- Elovl6 exhibits tumor-suppressive effects, inhibiting cellular proliferation in vitro and tumor growth in vivo.
- It maintains intestinal microbial homeostasis and modulates phospholipid biosynthesis pathways for metabolic reprogramming.
- Stearic acid, a metabolite of Elovl6, promotes mitochondrial fusion by stabilizing mitofusin 1 protein.
- Elovl6 is suggested as a therapeutic target, with stearic acid supplementation proposed for CRC prevention and treatment.