Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation - PubMed

4 hours ago

Phagocytosis is a fundamental biological process present across various organisms, from ameba to mammalian cells.
In the central nervous system (CNS), phagocytosis plays a key role in maintaining homeostasis by removing excess synapses, apoptotic cells, and debris.
Phagocytosis has a dual role in CNS pathologies: it aids in debris removal and tissue repair but can also contribute to damage by engulfing viable synapses and cells and releasing cytotoxic mediators.
The review discusses the involvement of phagocytosis in conditions like multiple sclerosis, aging, Alzheimer's disease, traumatic CNS injury, and ischemic stroke.
Current and future clinical approaches aim to leverage phagocytosis to enhance CNS repair and improve neurological outcomes.

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