BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk - PubMed
4 hours ago
- #BGN/MDK axis
- #tumor microenvironment
- #melanoma
- The BGN/MDK axis in melanoma's tumor microenvironment enhances tumor malignancy by influencing interactions between cancer cells and cancer-associated fibroblasts (CAFs).
- BGN expression is upregulated by m6A modulators (YTHDF3, YTHDC1, METTL14) in melanoma cells, promoting proliferation and metastasis.
- CAFs exhibit the highest BGN expression in the tumor microenvironment, with myCAFsBGN-high potentially originating from iCAFsBGN-low to interact with melanoma cells.
- MDK signaling pathways are identified as key in the BGN-mediated regulation of CAFs, affecting CD8+ T cell infiltration.
- Pharmacological inhibition of MDK suppresses tumor growth and increases CD8+ T cell infiltration, suggesting therapeutic potential.
- The BGN/MDK axis can activate normal fibroblasts into a CAF-like phenotype, further driving melanoma malignancy.