Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement - PubMed
3 hours ago
- #colorectal-cancer
- #gut-liver-axis
- #MASLD
- MASLD is associated with an increased risk of colorectal cancer (CRC).
- Metabolic burden and severity of MASLD further increase CRC risk and worsen outcomes.
- The gut-liver axis, gut dysbiosis, leptin, and adiponectin play key roles in MASLD and CRC development.
- Potential risk-reduction strategies include weight loss, early CRC screening, bariatric surgery, and GLP-1 receptor agonists.
- Experts emphasize the need for earlier, risk-adapted screening and integrated metabolic management for CRC in MASLD patients.