Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents - PubMed
7 hours ago
- #obesity
- #ER stress
- #puberty
- Early-onset obesity in female rodents is linked to advanced puberty, increasing long-term health risks.
- Hypothalamic endoplasmic reticulum (ER) stress plays a key role in obesity-induced precocious puberty.
- Female rats with early-onset obesity showed altered ER stress markers (increased p-PERK, p-eIF2α, reduced ATF6α).
- Central stimulation of ER stress in lean female rats mimicked obesity-induced advanced puberty without weight changes.
- ER stress alleviation in the hypothalamic arcuate nucleus (ARC) prevented obesity-induced precocious puberty.
- Kiss1 neurons in early-overfed juvenile mice showed increased Perk and Ire1α mRNA levels.
- The Xbp1s/u expression ratio rose significantly during juvenile-pubertal transition in overweight mice.
- Hypothalamic ER stress is crucial in controlling female puberty and obesity-related pubertal alterations.