Semaglutide Alleviates Age-Related Dry Eye Disease by Restoring Lacrimal Gland Structure and Function - PubMed
a day ago
- #Cellular Senescence
- #Semaglutide
- #Dry Eye Disease
- Semaglutide (Sema) shows potential in treating age-related dry eye disease (DED) by restoring lacrimal gland (LG) function.
- Long-term Sema treatment in aged mice alleviates DED symptoms and preserves LG structural integrity.
- Single-cell transcriptomic analyses reveal Sema attenuates cellular composition changes and senescence in LGs.
- Sema reduces senescent cell burden, oxidative stress, and inflammation in LGs.
- Mechanistically, Sema enhances stress adaptation in acinar cells and suppresses fibrosis and inflammation in fibroblasts and macrophages.
- Findings suggest Sema as a potential therapeutic for age-related DED by targeting cellular senescence.