FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy - PubMed
a day ago
- #DNA repair
- #ATR inhibitors
- #Oncoproteins
- FET fusion oncoproteins disrupt DNA repair mechanisms in cancers.
- EWSR1::FLI1, a FET fusion oncoprotein in Ewing sarcoma, impairs ATM signaling at DNA double-strand breaks.
- Compensatory ATR signaling is identified as a therapeutic target in FET rearranged cancers.
- ATR inhibitors show promise in preclinical models for treating FET rearranged cancers.
- Ongoing early phase clinical trials are testing ATR inhibitors in these cancers.