Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy - PubMed
6 days ago
- #PGNMID
- #daratumumab
- #monoclonal gammopathy
- A rare case of a 50-year-old male patient with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) was reported.
- The patient showed inconsistency between serum IgG κ and glomerular IgA λ chain types.
- Treatment with daratumumab, bortezomib, and dexamethasone led to clinical improvement, reducing serum free light chain (FLC) levels and stabilizing blood creatinine.
- This case highlights the potential of daratumumab as a promising treatment for PGNMID, despite limited data on its use in such conditions.
- The patient's condition was diagnosed through renal biopsy, revealing IgA λ-type PGNMID with acute tubulointerstitial injury and chronic disease.