PRMT6 is required for initiating and amplifying macrophage-induced inflammation in heterotopic ossification by increasing CCL2 expression - PubMed
2 days ago
- #macrophage inflammation
- #PRMT6
- #heterotopic ossification
- PRMT6 plays a critical role in initiating and amplifying macrophage-induced inflammation in heterotopic ossification (HO).
- Macrophage-driven inflammation is essential for HO pathogenesis, with rapid accumulation at injury sites post-trauma.
- Genetic deletion or knockdown of PRMT6 in macrophages reduces their accumulation and significantly attenuates HO formation.
- Pharmacological inhibition of PRMT6 is effective only during the early inflammatory phase, indicating a narrow therapeutic window.
- PRMT6 upregulates CCL2 expression, enhancing macrophage chemotactic signaling, crucial for HO development.
- PRMT6 forms a coactivation complex with NF-κB and catalyzes histone modifications to sustain CCL2 expression.
- Targeting PRMT6 early in inflammation could prevent HO while allowing normal tissue repair.