Neuroprotective response against the onset of ischemic stroke by upregulation of histone H3Y99 sulfation - PubMed
3 hours ago
- #histone sulfation
- #ischemic stroke
- #neuroprotection
- Histone H3Y99 sulfation is upregulated as a protective response against ischemic stroke.
- The SLC26A1-PAPSS1-SULT1B1 axis mediates sulfate transport, conversion to PAPS, and histone sulfation (H3Y99sulf).
- Upregulated H3Y99sulf enhances metabolic gene transcription and glycolysis, aiding cell survival during ischemia.
- PAPSS1 overexpression and sulfate supplementation reduce brain injury and improve neurological functions in mice.
- Disruption of H3Y99sulf worsens ischemia-induced brain injury and negates sulfate's neuroprotective effects.
- Ischemia patients with higher serum sulfate levels have smaller infarcts and better outcomes.
- This study identifies a new protective mechanism that could be targeted for stroke treatment.