Skin Metabolism of Linoleic Acid: Enzymatic Pathways and Roles in Skin Homeostasis - PubMed
4 hours ago
- #lipid-metabolism
- #skin-homeostasis
- #linoleic-acid
- Linoleic acid (LA) is the most abundant polyunsaturated fatty acid (PUFA) in human skin and is crucial for maintaining cutaneous homeostasis.
- Dysregulation of LA and its metabolites is linked to skin disorders like acne vulgaris, atopic dermatitis, and psoriasis vulgaris.
- LA undergoes three primary metabolic transformations in skin tissue: β-oxidation, lipid biosynthesis/conversion, and enzymatic non-catabolic oxidation to form bioactive lipid mediators.
- In the epidermis, LA primarily influences keratinocyte function through lipid biosynthesis and enzymatic oxidation pathways.
- In the dermis, LA predominantly affects sebaceous gland cells via β-oxidation and lipid biosynthesis/conversion pathways.
- Key areas for future research include crosstalk between non-catabolic oxidative routes, regulatory mechanisms of Lipoxygenases, and the roles of LA versus arachidonic acid (AA) in sebocyte regulation.
- Oxidative stress may positively modulate sebum production, adding complexity to LA-mediated lipid signaling networks.