Bridging innate immunity and iron-dependent death: the interplay between cyclic GMP-AMP synthase-stimulator of interferon genes nexus and ferroptosis in cancer and inflammation - PubMed
4 hours ago
- #cGAS-STING
- #cancer
- #ferroptosis
- The cGAS-STING pathway and ferroptosis are key mechanisms in cellular homeostasis and disease.
- cGAS-STING detects cytosolic DNA, triggering immune responses via TBK1-IRF3 and NF-κB signaling.
- Ferroptosis is an iron-dependent cell death marked by lipid peroxidation and antioxidant failure.
- There is significant crosstalk between cGAS-STING and ferroptosis pathways.
- The review explores structural bases, bridging molecules, and therapeutic strategies targeting this crosstalk in cancer.