Long-term feeder cell-free cat intestinal organoid cultures to study Toxoplasma gondii's sexual development - PubMed
8 days ago
- #feline intestinal organoid
- #Toxoplasma gondii
- #sexual development
- Toxoplasma gondii's sexual reproduction occurs exclusively in feline intestines.
- Transcription factors AP2XII-1 and AP2XI-2 are crucial for pre-sexual development.
- A feeder cell-free feline intestinal organoid culture system was developed to study T. gondii's sexual development.
- Elevated levels of sexual stage-specific transcripts were found in the organoid model.
- The model provides a controlled system to uncover host factors and mechanisms of T. gondii's sexual development.