PHB2 acts as a braker of progressive pulmonary fibrosis via intervention of DDR2-elicited signaling - PubMed
3 hours ago
- #DDR2
- #PHB2
- #pulmonary fibrosis
- PHB2 inhibits DDR2 tyrosine phosphorylation and TGF-β1 signaling pathways.
- PHB2 overexpression shows therapeutic effects in a mouse model of pulmonary fibrosis.
- PHB2 levels are significantly reduced in idiopathic pulmonary fibrosis (IPF) lungs.
- PHB2 disrupts DDR2 and TGFBR2 interaction, reducing fibrotic responses.
- PHB2 acts as a molecular brake on TGF-β1 and DDR2 profibrotic pathways.