Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection - PubMed
6 hours ago
- #Host-Pathogen Interaction
- #Pseudomonas aeruginosa
- #Antibiotic Resistance
- Carbapenem-resistance mutations in the OprD porin of Pseudomonas aeruginosa can emerge without prior carbapenem exposure.
- These mutations enhance the bacteria's ability to attach to and cross airway epithelial barriers in human infection models.
- Loss of OprD alters outer membrane charge and reduces mucus entrapment, promoting colonization.
- The findings show that antibiotic resistance mutations impact infection dynamics beyond just reducing drug susceptibility.