Organ-specific proteomic aging clocks predict disease and longevity across diverse populations - PubMed
3 hours ago
- #Biomarkers
- #Proteomics
- #Aging Clock
- Organ-specific proteomic aging clocks, developed from plasma proteomics and machine learning, accurately predict aging in the UK Biobank and are validated in diverse cohorts from China and the USA.
- Accelerated organ aging is linked to disease onset, progression, and mortality, with brain aging showing the strongest association with mortality.
- Brain aging is influenced by lifestyle factors, genetics (GABBR1 and ECM1 genes), and brain structure, reflecting both genetic and environmental determinants.
- The brain aging clock can stratify Alzheimer's disease risk across APOE haplotypes, suggesting super-youthful brains may confer resilience to APOE4.
- Proteomic organ aging clocks provide a biologically interpretable framework for tracking aging and disease risk across different populations.