Cardiac lymphatic dysfunction and repair in cardiovascular disease - PubMed
3 hours ago
- #Cardiac Lymphatics
- #Lymphangiogenesis
- #Cardiovascular Disease
- Cardiac lymphatic research has expanded significantly in the past decade.
- Clinical studies show lymphatic remodeling in various cardiovascular diseases.
- Structural alterations often lead to lymphatic transport dysfunction.
- Insufficient lymphatic drainage affects myocardial fluid balance, immune microenvironment, collagen turnover, and lipid handling.
- Review summarizes current knowledge on cardiac lymphatics, including their structural and molecular specializations.
- Effects of inflammation on lymphatics and mechanisms of lymphatic modulation of immunity are discussed.
- Regulation of cardiac lymphangiogenesis involves immune cell-lymphatic crosstalk, metabolic, and biomechanical stimulation.
- Experimental approaches to therapeutic lymphangiogenesis and their limitations are reviewed.
- Future research areas include translating lymphatic imaging and lymphangiogenic therapies to clinical practice.