PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment - PubMed
3 hours ago
- #immunotherapy
- #glioblastoma
- #PAK4
- PAK4 acts as an immune suppressor in glioblastoma by altering CD8+ T cell metabolism.
- PAK4 promotes TGF-β1 release, activating PI3K/AKT/NF-κB in CD8+ T cells, leading to PLA2G4A upregulation.
- PLA2G4A causes phosphatidylcholine depletion, impairing mitochondrial and lysosomal functions in CD8+ T cells.
- Inhibiting PLA2G4A reduces CD8+ T cell exhaustion and enhances their cytotoxic ability.
- Combining PAK4 inhibitor with anti-PD-L1 therapy improves CD8+ T cell function and suppresses tumor growth.