The deubiquitinase YOD1 in cardiomyocytes mediates septic cardiomyopathy by deubiquitinating and thus stabilizing the NLRP3 inflammasome - PubMed
4 hours ago
- #YOD1
- #septic cardiomyopathy
- #NLRP3 inflammasome
- YOD1 expression increases in cardiac tissues of septic mice models.
- Cardiomyocyte-specific YOD1 knockout alleviates septic cardiomyopathy and protects cardiac function.
- YOD1 interacts with NLRP3, deubiquitinates it, and stabilizes it by blocking degradation.
- NLRP3 activation and pyroptosis are increased in septic hearts, mediated by YOD1.
- Inhibition of NLRP3 counteracts the protective effects of YOD1 knockout.
- Pharmacological inhibition of YOD1 improves myocardial injury in septic mice.
- YOD1-NLRP3 axis is a new therapeutic target for septic cardiomyopathy.