Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation - PubMed
3 hours ago
- #Biomarkers
- #Exosome
- #ITP
- Primary Immune Thrombocytopenia (ITP) is an autoimmune disease causing thrombocytopenia and bleeding.
- Exosome-related genes (ERGs) may serve as biomarkers for ITP pathogenesis.
- Four candidate genes (GABARAPL1, SLC39A14, HIBADH, GSR) were identified via bioinformatics.
- GABARAPL1, SLC39A14, and GSR showed significant downregulation in ITP patients via RT-qPCR.
- HIBADH did not show significant changes in ITP patients.
- Molecular docking suggested potential binding of SLC39A14/nortriptyline and GSR/oxiglutatione.
- The study provides preliminary insights into exosome-related genes in ITP.