Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy - PubMed
3 hours ago
- #extracellular vesicles
- #neurodegenerative diseases
- #CNS therapy
- Small extracellular vesicles (sEVs) mediate intercellular communication in the CNS and play dual roles in neurodegenerative disease pathology and therapy.
- In neurodegenerative diseases like Alzheimer's and Parkinson's, sEVs spread pathogenic proteins and nucleic acids, contributing to disease propagation.
- sEVs are promising nanocarriers for CNS drug delivery due to their biocompatibility, ability to cross brain barriers, and organotropic properties.
- Neural cell-derived sEVs (from neural stem cells, neurons, astrocytes, etc.) may offer better brain targeting and therapeutic efficacy than those from mesenchymal stem cells.
- The review covers sEVs' physiological roles in brain homeostasis, involvement in disease, and therapeutic applications, including engineering strategies for enhanced performance.
- Key translational challenges for clinical implementation are addressed, highlighting sEVs as a versatile platform for advancing neuro-nanomedicine.