Repetitive transcranial magnetic stimulation modulates neuroinflammation and cell apoptosis via the interaction between Ifit3 and Stat1 for the treatment of neuropathic pain - PubMed
4 hours ago
- #rTMS
- #Neuropathic pain
- #Neuroinflammation
- Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique used to treat neuropathic pain (NeuP), but its therapeutic mechanism is not fully understood.
- Transcriptomic and proteomic analyses on rat brain tissues with chronic constriction injury (CCI) models identified Ifit3 and Stat1 as key regulatory molecules.
- rTMS significantly reduced elevated levels of Ifit3 and Stat1 in NeuP rats, mitigating neuroinflammation and microglial apoptosis.
- Overexpression of Ifit3 worsened inflammation and apoptosis, while silencing Ifit3 had a mitigating effect.
- Stat1 expression changes were highly consistent with Ifit3, indicating their interaction plays a pivotal role in rTMS therapeutic effects.
- The study suggests rTMS treats NeuP by modulating inflammation and apoptosis via the Ifit3-Stat1 interaction.