Charge-reversal proteolysis polymers enable tissue-specific STING degradation in rheumatoid arthritis - PubMed
7 hours ago
- #pH-responsive materials
- #STING degradation
- #rheumatoid arthritis
- Charge-reversal proteolysis polymers (CreTACs) enable tissue-specific STING degradation for rheumatoid arthritis (RA) treatment.
- CreTACs utilize pH-programmed charge inversion to enhance delivery to RA sites, increasing joint accumulation by 7.5-fold.
- The system minimizes systemic toxicity by remaining electroneutral in circulation (pH 7.4) and activates in acidic environments (pH 6.5).
- CreTACs outperform methotrexate in collagen-induced arthritis models, reducing synovitis and bone erosion without hematological toxicity.
- This multilevel charge reversal strategy offers a blueprint for next-generation drug-delivery systems and biomaterials.