Gut microbiota and ulcerative colitis: a bibliometric analysis of knowledge structure, research hotspots, and future directions - PubMed
3 hours ago
- #bibliometric analysis
- #gut microbiota
- #ulcerative colitis
- Gut microbiota and ulcerative colitis (UC) are fundamentally linked, with UC being a prevalent immune-mediated colonic disorder.
- A bibliometric analysis of 5,879 articles from 2004-2025 reveals exponential growth in publications, from 36 in 2004 to a projected 819 in 2024.
- China and the USA dominate global research output, accounting for 63.6% of publications, with Harvard Medical School leading in citation efficiency.
- Key research frontiers include fecal microbiota transplantation (FMT), short-chain fatty acids, traditional Chinese medicine, intestinal barrier mechanisms, and nanoparticle-based microbiota modulation.
- Recent trends (2023-2025) show a shift from descriptive microbiome profiling to mechanistic, precision-targeted interventions, particularly in nanoparticles and intestinal barrier research.
- Future directions emphasize standardizing FMT protocols, multi-ethnic longitudinal cohorts, microbial metabolite dose-response relationships, and integrating nanodelivery systems with microbiome engineering.