Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer - PubMed
3 hours ago
- #Colorectal cancer
- #Autoimmune diseases
- #Mendelian randomization
- Bidirectional Mendelian randomization analysis was used to explore causal links between autoimmune diseases (AIDs) and colorectal cancer (CRC).
- Celiac disease (CD) was associated with a reduced risk of CRC (OR = 0.94; 95% CI, 0.89-0.99; P = 0.028).
- Rheumatoid arthritis (RA) was associated with an increased risk of CRC (OR = 1.06; 95% CI, 1.02-1.11; P = 0.004).
- No significant causal associations were found for other AIDs, including SLE, AS, gout, MS, eczema, and asthma.
- Reverse MR analysis showed no evidence that CRC genetic risk influences AIDs.
- Sensitivity analyses confirmed the robustness of the findings.
- The study suggests immune dysregulation, inflammation, and dietary factors may underlie these associations.