Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation - PubMed
2 hours ago
- #PP2A degradation
- #SCF ubiquitin ligase
- #cryo-EM structure
- SCFFBXO42 degrades free PP2Ac via CCDC6 to regulate phosphatase activity.
- Cryo-EM shows CCDC6 forms a dimeric template binding PP2Ac for FBXO42 recognition.
- Multivalent assembly along CCDC6 enables efficient ubiquitination and degradation of PP2Ac.