Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs - PubMed
4 hours ago
- #Treg depletion
- #Timosaponin AIII
- #CAR-T cell therapy
- Timosaponin AIII (TAIII) enhances CAR-T cell potency and prevents relapse in cancer therapy.
- TAIII depletes CAR-Tregs and enhances effector activity by acting as an allosteric A2AR inhibitor.
- Mechanism involves suppression of CREB-dependent FoxP3 transcription and disruption of the A2AR-Treg axis.
- TAIII reduces intratumoral Tregs, increases CD8 T-cell infiltration, and potentiates PD-1 blockade.
- It promotes central memory T-cell formation and enhances cytotoxic cytokine secretion in CAR-T cells.
- Combining or pretreating CAR-T cells with TAIII improves antitumor efficacy and prevents late relapse.