TMEM187 is a novel modulator in the regulation of erythropoiesis - PubMed
7 hours ago
- #TMEM187
- #erythropoiesis
- #iron metabolism
- TMEM187 is identified as a novel negative regulator of erythropoiesis.
- Lack of TMEM187 accelerates iron uptake and initiates erythropoiesis without normal induction.
- TMEM187 ablation causes premature erythroid maturation, leading to cellular senescence and phagocytosis susceptibility.
- In zebrafish, tmem187 deletion enhances early erythropoiesis but is later compensated.
- Human TMEM187 expression in mice results in compromised erythropoiesis and moderate anemia.
- TMEM187 interacts with RAB11 to restrain endosomal recycling, modulating TfR1 recycling and iron uptake efficiency.