Lipoprotein(a) levels in children with hypercholesterolemia - PubMed
4 hours ago
- #Pediatrics
- #Hypercholesterolemia
- #Cardiovascular Disease
- Lipoprotein(a) [Lp(a)] is a significant genetic risk factor for cardiovascular disease (CVD).
- Extremely high Lp(a) levels (153mg/dL) can elevate LDL-C due to structural similarities between Lp(a) and LDL-C particles.
- The study included 1,418 children with hypercholesterolemia, categorized into definite FH, possible FH, and definite non-FH groups.
- Elevated Lp(a) levels (>30 mg/dL) were found in 25.1% of definite FH and 34.9% of possible FH cases.
- Lp(a) contributed to LDL-C levels in 32.7% of definite FH cases and to Apolipoprotein B in 18.6%.
- After adjusting for Lp(a), elevated LDL-C (>3.5 mmol/L) persisted in 88.4% of definite FH and 30.4% of possible FH children.
- One in four children with FH and one in three with polygenic hypercholesterolemia have elevated Lp(a) levels.
- Modifiable CVD risk factors (elevated LDL-C and obesity) are already present in these children, necessitating early evaluation and management.
- Universal Lp(a) measurement is essential, as screening only hypercholesterolemic children for high Lp(a) is insufficient.