Quercetin targets the TNF-a/TNF pathway to activate mitochondrial autophagy to improve nucleus pulposus cell function and delay disc degeneration - PubMed
4 hours ago
- #Quercetin
- #Mitochondrial Autophagy
- #Intervertebral Disc Degeneration
- Quercetin, a main component of Tong'an decoction, targets the TNF-α/TNF pathway to activate mitochondrial autophagy.
- It improves nucleus pulposus cell function and delays intervertebral disc degeneration (IVDD) by reducing inflammation and reversing fibrosis.
- Multi-omics techniques identified 677 IVDD-related autophagy genes, including HIF1A, TNF, BCL2, and LC3, involved in mitochondrial autophagy and inflammatory pathways.
- Quercetin intervention alleviates mitochondrial dysfunction and autophagy dysregulation caused by inflammatory stimulation in both animal and cell models.
- The study provides a 'components-targets-phenotype' proof chain for Tong'an Tang's therapeutic effects on IVDD, supporting clinical translation.