Development of a Diagnostic Autoantibody Assay to a Consensus Motif for the Risk Prediction of Epstein-Barr Virus-Related Multiple Sclerosis - PubMed
3 hours ago
- #Autoantibody Assay
- #Multiple Sclerosis
- #Epstein-Barr Virus
- Development of an autoantibody assay targeting a specific motif for predicting Epstein-Barr Virus-related Multiple Sclerosis (MS).
- Discovery of a monoclonal antibody (mAb) from MS patient memory B cells binding to the MS signature motif with high affinity.
- Development of a Luminex xMAP autoantibody test with high sensitivity and specificity for MS diagnosis.
- Identification of EBV tegument protein BRRF2 and human vimentin as cross-reactive antigens linked to MS.
- Potential utility of the assay in early MS detection and integration with other biomarkers for predictive risk scoring.