RETREG1-Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis - PubMed
4 hours ago
- #dendritic cells
- #sepsis
- #autophagy
- RETREG1-mediated reticulophagy is crucial for dendritic cell (DC) maturation and function in sepsis.
- Activating transcription factor 6 (ATF6) regulates RETREG1 expression in response to bacterial lipopolysaccharide-induced ER stress.
- RETREG1-mediated reticulophagy reduces excessive ER stress via the EIF2AK3 signaling pathway.
- RETREG1 inhibits MARCH8-dependent MHC-II ubiquitination, maintaining antigen presentation in DCs.
- Mice with deficiencies in RETREG1 or ATF6 show impaired DC function, leading to immunosuppression and organ failure in sepsis.
- Human sepsis samples and single-cell analysis suggest a link between reticulophagy deficits in DCs and sepsis development.