Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteremia: external validation with decision curve analysis - PubMed
5 hours ago
- #Enterococcus faecalis
- #Risk stratification
- #Infective endocarditis
- The DENOVA score was externally validated for predicting infective endocarditis (IE) in patients with Enterococcus faecalis bacteremia (EfB).
- The study included 543 patients from 23 centers across six countries, with 23.0% diagnosed with IE.
- The DENOVA score showed an AUC of 0.871, with sensitivity of 79.2% and specificity of 83.0% at the threshold of ≥3.
- Decision curve analysis (DCA) indicated positive net clinical benefit, reducing unnecessary transesophageal echocardiograms (TEEs).
- The DENOVA score supports risk stratification and clinical decision-making for IE in EfB patients.