Electrogram-guided Pulsed Field Ablation for Persistent Atrial Fibrillation: A Prospective Cohort Study - PubMed
7 hours ago
- #Electrogram-guided Ablation
- #Pulsed Field Ablation
- #Persistent Atrial Fibrillation
- Study explores electrogram (EGM)-guided pulsed field ablation (PFA) for persistent atrial fibrillation (PerAF).
- Two groups compared: EGM-guided PFA (PVI, PWI, target EGM ablation) vs. anatomical PVI plus PWI.
- EGM group showed higher intra-procedural AF termination (84.7%) vs. PWI group (11.8%).
- At 12 months, AF/AT-free survival was 82.4% in EGM group vs. 65.9% in PWI group.
- Patients with procedural AF termination had higher AF/AT-free survival (84.1%) vs. non-termination (64.8%).
- Primary safety endpoint: 1.2% adverse event rate in EGM group (hemolysis).
- EGM-guided PFA demonstrated preliminary efficacy and safety for PerAF ablation.