Metabolic-epigenetic regulation of TRPM3 via H3K18 lactylation in dorsal root ganglia mediates bone cancer pain and its attenuation by microwave ablation - PubMed
4 hours ago
- #bone cancer pain
- #histone lactylation
- #microwave ablation
- Bone metastatic pain in lung cancer is linked to a tumor metabolism-neural epigenetic-ion-channel axis.
- Patients with higher pain showed glycolysis enrichment in tumor cells and increased lactylation in dorsal root ganglia (DRG).
- Lactate signaling in mice induces DRG lactylation and hypersensitivity, while its inhibition reduces pain.
- H3K18 lactylation at the Trpm3 promoter in DRG upregulates TRPM3, which mediates thermal and mechanical pain behaviors.
- Microwave ablation (MWA) of tumors provides analgesia, reduces DRG H3K18 lactylation and TRPM3, and suppresses tumor glycolytic proteins.