Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice - PubMed
19 hours ago
- #senescence
- #aging
- #cognitive health
- Tomatidine, found in tomatoes, is a newly identified senotherapeutic compound that targets cellular senescence.
- It reduces senescence markers and inflammation in aged mice, improving cognitive function, motor coordination, and frailty.
- The compound preserves blood-brain barrier integrity by diminishing endothelial cell senescence and enhancing tight junction proteins.
- Tomatidine acts as a senomorphic, suppressing SASP expression without affecting p16Ink4a or p21Cip1 levels in senescent cells.