KRAS Variant Frequency and Colorectal Cancer-Specific Survival by Race and Ethnicity - PubMed
7 hours ago
- #KRAS Variant
- #Health Disparities
- #Colorectal Cancer
- Colorectal cancer is the third most commonly diagnosed cancer and the third leading cause of cancer-associated deaths in the US.
- Hispanic and non-Hispanic Black patients experience higher colorectal cancer mortality rates compared with non-Hispanic White patients.
- The study evaluated racial and ethnic differences in KRAS variant frequency and its association with colorectal cancer-specific survival.
- Data from the Surveillance, Epidemiology, and End Results Program included patients diagnosed with colorectal cancer from 2010 through 2015.
- Hispanic and non-Hispanic Black patients had higher KRAS variant frequencies than non-Hispanic Asian or Pacific Islander and non-Hispanic White patients.
- Among patients with KRAS wild-type tumors, Hispanic patients had the highest cumulative incidence of colorectal cancer-specific death.
- Among patients with KRAS variant tumors, non-Hispanic Black patients had the highest cumulative incidence of colorectal cancer-specific death.
- The findings highlight the need for further research on racial and ethnic differences in KRAS-related outcomes.