WWP2 underlies ROS-induced granulosa cell apoptosis by promoting ubiquitination of BAK in polycystic ovary syndrome - PubMed
3 hours ago
- #PCOS
- #Granulosa cell apoptosis
- #Oxidative stress
- WWP2 expression is significantly reduced in PCOS and plays a role in granulosa cell apoptosis.
- Oxidative stress weakens the interaction between WWP2 and BAK, reducing BAK ubiquitination at Lys113.
- Disrupting BAK ubiquitation or knocking down WWP2 facilitates granulosa cell apoptosis in PCOS.
- Genetic ablation of Wwp2 in PCOS mice worsens granulosa cell apoptosis and hormonal disturbances.
- WWP2 is identified as a potential therapeutic target for PCOS due to its role in modulating mitochondrial apoptosis.