CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma - PubMed
4 hours ago
- #Transcriptional Regulation
- #DNA Replication
- #Glioblastoma
- CDK12/CDK13 inhibition selectively targets glioblastoma stem cells (GSCs), halting proliferation, invasion, and tumor growth in mouse models.
- Inhibition causes loss of RNAPII CTD serine-2 phosphorylation (pSer2), disrupting transcriptional elongation and neurodevelopmental transcription factor programs.
- It unexpectedly arrests DNA replication and fork progression, linking transcriptional regulation to replication dynamics in GSCs.