Genetic influences on haematopoiesis - PubMed
3 hours ago
- #genetics
- #haematopoiesis
- #blood disorders
- Haematopoiesis serves as a model for understanding genetic variation's impact on health and disease.
- Genetic studies range from Mendelian blood disorders to population-scale genomic research on blood cell traits.
- Single-cell genomics and variant-to-function mapping provide insights into genetic influences on blood cell development.
- Somatic mutations in haematopoietic stem cells lead to clonal haematopoiesis, affecting function and disease risk.
- Genetic research in haematopoiesis is advancing treatments for monogenic blood disorders and broader applications.
- Haematopoiesis remains key to studying genetic variation's role in biology, disease susceptibility, and therapy response.