Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types - PubMed
7 days ago
- #genomics
- #mutational signatures
- #cancer research
- Whole-genome sequencing (WGS) reveals oncogenic processes through mutation patterns.
- Mutational signatures offer insights into tumor causes and potential treatment targets.
- Study includes 10,983 patients across 16 cancer types from the 100,000 Genomes Project.
- Identifies 134 signatures across five mutation classes, with 26 new to COSMIC.
- Introduces a structural variation (SV) signature reference set.
- Connects signatures to genomic features and clinical data for precision oncology applications.