Propofol versus ketamine in rapid sequence intubation in critically ill patients: a prospective, randomized, controlled trial - PubMed
4 hours ago
- #Rapid Sequence Intubation
- #Anesthesia
- #Critical Care
- The study compared Ketamine and Propofol for rapid sequence intubation (RSI) in critically ill patients.
- Primary outcome was the lowest mean arterial pressure (MAP) within the first 10 minutes post-induction.
- Ketamine showed a less pronounced decrease in MAP (66 mmHg) compared to Propofol (60 mmHg), but the difference was not clinically significant.
- Cardiovascular collapse occurred in 22% of Ketamine-treated patients vs. 33% in Propofol-treated patients.
- Day-7 mortality was higher with Ketamine (33%) than Propofol (23.8%), but hospital mortality rates were 60.4% and 50% respectively.
- The study concluded that sedative selection should not be based solely on the risk of hypotension and called for larger trials.
- Ethical approval was obtained, and informed consent was secured from participants or their representatives.