Refining BCG-failure classifications in non-muscle-invasive bladder cancer - PubMed
4 hours ago
- #BCG-failure
- #prognostic heterogeneity
- #NMIBC
- Study validates IBCG definitions for BCG-unresponsive and BCG-exposed NMIBC.
- Analysis of 591 patients shows similar PFS, CSM, and OM between BCG-unresponsive and BCG-exposed groups.
- Prognostic heterogeneity found across five BCG-failure subgroups with varying 5-year progression rates.
- BCG-exposed after inadequate BCG, late relapse, and BCG-unresponsive linked to higher progression risks.
- Very late relapses (>24 months) show better prognosis compared to other subgroups.
- Study highlights the need for refined classification in BCG-failure NMIBC for better prognostic assessment.