Integrated network pharmacology, metabolomics, and transcriptomics of Lianpuyin Jiawei Decoction in Helicobacter pylori induced chronic gastritis - PubMed
3 hours ago
- #Helicobacter pylori
- #chronic gastritis
- #traditional Chinese medicine
- Lianpuyin Jiawei Decoction (LPYJWD) is studied for treating Helicobacter pylori-induced chronic gastritis using integrated multi-omics approaches.
- 38 potential bioactive components in LPYJWD were identified via UPLC-MS/MS as key therapeutic agents.
- LPYJWD alleviates gastric mucosal inflammation and tissue damage in H. pylori-induced mouse models.
- Metabolomics shows LPYJWD affects pathways like glycolysis, pentose phosphate, arginine, arachidonic acid, and glycerophospholipid metabolism.
- Network pharmacology and transcriptomics indicate LPYJWD acts via IL-17, TNF, NLRP3, and NF-cB signaling pathways.
- Experimental validation confirms LPYJWD inhibits the IL-17/NF-cB/NLRP3 pathway to reduce inflammation.