Unraveling the root causes of HIV-1 persistence - PubMed
3 days ago
- #HIV-1 persistence
- #antiretroviral therapy
- #viral latency
- ART suppresses HIV-1 viral loads but cannot eliminate the reservoir of infected cells.
- HIV-1 persistence is due to viral latency, clonal expansion, cell-intrinsic survival programs, immune evasion, and protective tissue microenvironments.
- Recent technologies like proviral sequencing and single-cell multiomics have expanded understanding of HIV-1 reservoirs.
- No single factor drives HIV-1 persistence; it is a result of interconnected mechanisms.
- Future interventions need to target the multilayered network sustaining the viral reservoir.