Association of Systemic Inflammatory Indices with Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis - PubMed
3 hours ago
- #Liver Fibrosis
- #Systemic Inflammation
- #MASLD
- The study explores the association between systemic inflammatory indices and metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis.
- Systemic inflammatory indices such as SII, SIRI, PLR, LMR, PNI, AISI, IBI, and PIV were analyzed in relation to MASLD and liver fibrosis.
- Elevated SII, SIRI, LMR, IBI, and PNI were significantly associated with higher hepatic steatosis (CAP values), while PLR showed a negative association.
- Higher SIRI, PNI, IBI, and AISI were significantly linked to increased liver stiffness (LSM), indicating liver fibrosis, with PLR inversely related.
- The findings suggest systemic inflammatory dysregulation is connected to both MASLD and liver fibrosis, with distinct biomarker patterns for each condition.